Yes you should be concerned about insects and take proper precautions.
Soak all of your clothes in permethrin and let them dry. It is so easy to do this and it will make a bigger difference than almost anything else you do. I don't only soak my socks as some people do because they can come off brush onto pants, or taller brush and trees onto shirts. I soak them vs. spray them to get it to last longer. It has been my experience that soaking them gets them to last an entire "season", as in all of fall, or all of summer, etc.
Some of the animals seem to not have any ticks on them, and some seem to be absolutely covered. When you roll over a Kudu and see their skin crawling from all the ticks running around in the hair trying to relocate, you will be glad you used permethrin.
I also take a couple small cans of spray in case flying bugs or something else are thick and aren't warded off by permethrin. But it isn't usually necessary.
Talk to your doctor about travel meds, if your hospital has a travel clinic that usually makes it easy. Often they will give you 2-3 prescriptions like an antibiotic for stomach bugs and also doxycycline (also an antibiotic) which is a prophylactic for malaria, but it is also a treatment for tick borne illnesses. There are possible side effects to Doxy that are worth considering, such as it can discolor your teeth, and it can make you sensitive to sun. I have taken doxy with me, with the plan of only taking it if I found a tick bite. I would have considered adjusting my plan if I were going to be in a very malaria prone area, but most of SA is not.